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Biological and targeted-synthetic disease-modifying antirheumatic drugs with concomitant methotrexate or leflunomide in rheumatoid arthritis: Real-life TReasure prospective data
Kimyon, G.; Kalyoncu, Umut; Kiraz, Sedat; Bes, Cemal; Coşkun, Necdet; Yagiz, B.; Kelesoglu, B.; Mercan, Rıdvan (Clinical and Experimental Rheumatology S.A.S., 2021)Objective To determine the real-life efficacy, safety, and drug-retention rates of leflunomide (LEF) or methotrexate (MTX) as a synthetic DMARD used in combination with biological DMARDs for rheumatoid arthritis (RA). ... -
Imidazolidin-1-oles, N-2-aminoethyl nitrones and 1,2,5-oxadiazinanes. A novel ring-chain tautomerism
Coşkun, Necdet; Asutay, Oktay (Pergamon-Elsevier Science Ltd, 2007)Imidazolin-3-oxides I were reduced with NaBH4 in THF at reflux to give the corresponding 2,3,5-triarylimidazolidin-l-oles 2, which are proved to be in a ring-chain-ring tautomeric equilibrium with N-2-aminoethyl nitrones ... -
New Route to 20-Deethyldasycarpidone by Ring-Closure with DDQ
Uludağ, Nesimi; Sanda, Mustafa; Asutay, Oktay; Coşkun, Necdet (Taylor & Francis Inc, 2014)[No Abstract Available] -
Selective oxidative deoximation with anhydrous Ce(IV) sulfate
Asutay, Oktay; Hamarat, Nilufer; Uludağ, Nesimi; Coşkun, Necdet (Pergamon-Elsevier Science Ltd, 2015)Anhydrous Ce(SO4)(2) in chloroform selectively converts oximes into the parent carbonyl compounds in good yields. Hammett correlations helped to indicate a plausible mechanism for the above reaction. The formation of ... -
Selective reduction of 1,4-diarylimidazoline-3-oxides to imidazolidin-1-ols and hydroxylamine derivatives
Asutay, Oktay; Coşkun, Necdet (Springer Wien, 2010)C-2-unsubstituted imidazoline-3-oxides were reduced with NaBH4 in THF to give the corresponding trans-3,5-diarylimidazolidin-1-ols, while under the same conditions C-2-substituted derivatives gave the corresponding ...